ICRB 2006 - O2 sensing in hypoxia via HIF: a worm-to-man survey of physiological and pathophysiological aspects

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Lectures and Symposia updated June 12, 2006

Lectures:

Keynote Lecture: Gills, lungs and spiracles - fossil evidence for the evolution of air breathing

Plenary Lecture: Experimental Evolution as an Approach to Study Respiratory Biology

Plenary Lecture: Neuronal and Chemosensory Control of Breathing: Lessons Learned from a Simple Model System Approach

Plenary Lecture:
The Use of Molecular Tools in Integrative Respiratory Physiology

Symposia:

Homeostatic Responses to Changing Metabolic Demands

Developmental Transitions in Respiratory Physiology

Sensing CO₂, H+ and O₂; A Comparative Survey of Receptors and Pathways

The Integrative and Evolutionary Biology of Gas-Binding Proteins

Coping with Cyclic Oxygen Availability: Evolutionary Aspects

Directions in Respiratory Biology

Respiratory Plasticity after Changes in Oxygen Supply and Demand

Radicals and Foreign Airborne Substances

Innovative Methods in Respiratory Biology

Breathing during Locomotion

The Anatomy, Physics and Physiology of Gas Exchange Surfaces with Emphasis on Pulmonary Surfactant

Mitochondria and Respiration

Deconvoluting Lung Evolution: From Phenotypes to Gene Regulatory Networks

Reconfiguration of the Respiratory Network During Respiratory and Non-Respiratory Behaviours

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Imprint

O₂ Sensing in Hypoxia via HIF:
A Worm-to-Man Survey of Physiological and Pathophysiological Aspects
Thomas A. Gorr (University of Zürich, Switzerland)

The hypoxia-inducible transcription factor (HIF) has been described as key mediator for transducing changes in [O₂] onto DNA level from 'worms' (C. elegans), to flies (Drosophila), to fish (teleosts) and mammals. Surprisingly enough, HIF-driven gene regulations in response to acute and chronic deprivations of oxygen are also of central importance, despite markedly different physiological outcomes, in hypoxia-tolerant and -sensitive tissues or animals alike. Several disease states, e.g. cancer, are, compared to healthy tissue, commonly aggravated by hyperactive HIF signaling in association with a far more stress or treatment resistant and aggressive phenotype. Therefore, novel HIF functions and control mechanisms, which not only endow cells to withstand and recover from severe hypoxia but also keep the activity of this transcription factor within physiological limits, are becoming increasingly important research aspects in the field. O₂ sensing via HIF has obviously begun to link historically independent trajectories between comparative and clinically applied biology into a far more coherent, unifying outlook on hypoxia-mediated cellular adaptations.
To continue down this integrative path, our symposium aims to explore cellular and organismal adaptations to hypoxia, as conferred by the HIF signaling pathway, in a comparative manner. We also invite ideas and insights from invertebrate and vertebrate animal models that might apply to study or manipulate HIF signaling in human disease.

Keith Webster University of Florida Miami, USA	Hypoxia regulated stem cell therapy OR Hypoxia-mediated apoptosis
Jo-Anne Powell-Coffman Iowa State University Ames, USA	Genetic analysis of hypoxia signaling and response in C. elegans
Doris Abele Alfred Wegener Institute Bremerhaven, Germany	Constitutive HIF-1 levels in fish change upon thermal acclimation
Hideo Yamagata Tokio University of Pharmacy and Life Sciences Japan	Expression of HIF and hypoxic induction of hemoglobin in the crustacean Daphnia magna
Nora Terwilliger University of Oregon Eugene, USA	HIF-1 regulation in crustaceans
Thomas Hankeln University of Mainz Germany	Globins in Drosophila: respiratory proteins or oxygen scavengers or else?
Thomas Gorr University of Zürich Switzerland	Quo vadis HIF? Functions and controls of hypoxic signaling - from invertebrate models to human pathologies
Kalle Rytkönen University of Turku Finland	Evolution of hypoxia-inducible factor 1alpha in fishes
Sven Påhlman Lund University Malmö, Sweden	The Effect of Hypoxia on Tumor Phenotype and Tumor Behavior
Joachim Fandrey University Duisburg-Essen Germany	Imaging of the cellular oxygen sensor system
Patrick Maxwell Imperial College London UK	The role of HIF and VHL in cancer
Pablo Wappner University of Buenos Aires Argentina	Title to be announced
Katja Heise Alfred Wegener Institute Bremerhaven, Germany	The Hypoxia inducible factor (HIF-1) in cold-stenothermal Antarctic fishes